[HTML][HTML] Defective heparan sulfate biosynthesis and neonatal lethality in mice lackingN-deacetylase/N-sulfotransferase-1
M Ringvall, J Ledin, K Holmborn… - Journal of Biological …, 2000 - ASBMB
Heparan sulfate is a sulfated polysaccharide present on most cell surfaces and in the
extracellular matrix. In vivo functions of heparan sulfate can be studied in mouse strains
lacking enzymes involved in the biosynthesis of heparan sulfate. Glucosaminyl N-
deacetylase/N-sulfotransferase (NDST) catalyzes the first modifying step in the biosynthesis
of the polysaccharide. This bifunctional enzyme occurs in several isoforms. We here report
that targeted gene disruption of NDST-1 in the mouse results in a structural alteration of …
extracellular matrix. In vivo functions of heparan sulfate can be studied in mouse strains
lacking enzymes involved in the biosynthesis of heparan sulfate. Glucosaminyl N-
deacetylase/N-sulfotransferase (NDST) catalyzes the first modifying step in the biosynthesis
of the polysaccharide. This bifunctional enzyme occurs in several isoforms. We here report
that targeted gene disruption of NDST-1 in the mouse results in a structural alteration of …