The neglected role of type I interferon in the T-cell response: implications for its clinical use
F Belardelli, I Gresser - Immunology today, 1996 - Elsevier
Originally described as an antiviral substance, type I interferon (IFN) was subsequently
shown to exert multiple biological effects and is now the most frequently used cytokine in the
treatment of some viral and neoplastic diseases. Although early studies described various
effects on the immune system, the role of type I IFN as an immunoregulatory molecule has
long been neglected. Here, Filippo Belardelli and Ion Gresser summarize recent
experimental results on the interactions of type I IFN with T cells, which may prove important …
shown to exert multiple biological effects and is now the most frequently used cytokine in the
treatment of some viral and neoplastic diseases. Although early studies described various
effects on the immune system, the role of type I IFN as an immunoregulatory molecule has
long been neglected. Here, Filippo Belardelli and Ion Gresser summarize recent
experimental results on the interactions of type I IFN with T cells, which may prove important …