Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs
B Cryer, M Feldman - The American journal of medicine, 1998 - Elsevier
Purpose: Both isoforms of cyclo-oxygenase, COX-1 and COX-2, are inhibited to varying
degrees by all of the available nonsteroidal anti-inflammatory drugs (NSAIDs). Because
inhibition of COX-1 by NSAIDs is linked to gastrointestinal ulcer formation, those drugs that
selectively inhibit COX-2 may have less gastrointestinal toxicity. We measured the extent to
which NSAIDs and other anti-inflammatory or analgesic drugs inhibit COX-1 and COX-2 in
humans. Subjects and Methods: Aliquots of whole blood from 16 healthy volunteers were …
degrees by all of the available nonsteroidal anti-inflammatory drugs (NSAIDs). Because
inhibition of COX-1 by NSAIDs is linked to gastrointestinal ulcer formation, those drugs that
selectively inhibit COX-2 may have less gastrointestinal toxicity. We measured the extent to
which NSAIDs and other anti-inflammatory or analgesic drugs inhibit COX-1 and COX-2 in
humans. Subjects and Methods: Aliquots of whole blood from 16 healthy volunteers were …