Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other …
LAG Rodríguez, C Cattaruzzi… - Archives of internal …, 1998 - jamanetwork.com
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) cause substantial morbidity and
mortality from upper gastrointestinal tract disease. Ketorolac tromethamine has been singled
out as an NSAID with a distinct gastrotoxicity profile. Calcium channel blockers, a class of
antihypertensive drugs, have also been found to increase the risk of gastrointestinal tract
bleeding. Methods We identified 1505 patients hospitalized because of upper
gastrointestinal tract bleeding and/or perforation, and we randomly sampled 20000 controls …
mortality from upper gastrointestinal tract disease. Ketorolac tromethamine has been singled
out as an NSAID with a distinct gastrotoxicity profile. Calcium channel blockers, a class of
antihypertensive drugs, have also been found to increase the risk of gastrointestinal tract
bleeding. Methods We identified 1505 patients hospitalized because of upper
gastrointestinal tract bleeding and/or perforation, and we randomly sampled 20000 controls …