[HTML][HTML] NF-κB p105 processing via the ubiquitin-proteasome pathway
C Sears, J Olesen, D Rubin, D Finley… - Journal of Biological …, 1998 - ASBMB
The p50 subunit of NF-κB is generated by proteolytic processing of a 105-kDa precursor
(p105) in yeast and mammalian cells. Here we show that yeast mutants in the ubiquitin-
proteasome pathway inhibit or abolish p105 processing. Specifically, p105 processing is
inhibited by a mutation in a 20 S proteasome subunit (pre1-1), by mutations in the ATPases
located in the 19 S regulatory complexes of the proteasome (yta1, yta2/sug1, yta5, cim5),
and by a mutation in a proteasome-associated isopeptidase (doa4). A ubiquitinated …
(p105) in yeast and mammalian cells. Here we show that yeast mutants in the ubiquitin-
proteasome pathway inhibit or abolish p105 processing. Specifically, p105 processing is
inhibited by a mutation in a 20 S proteasome subunit (pre1-1), by mutations in the ATPases
located in the 19 S regulatory complexes of the proteasome (yta1, yta2/sug1, yta5, cim5),
and by a mutation in a proteasome-associated isopeptidase (doa4). A ubiquitinated …