Out of the ER—outfitters, escorts and guides
JM Herrmann, P Malkus, R Schekman - Trends in cell biology, 1999 - cell.com
JM Herrmann, P Malkus, R Schekman
Trends in cell biology, 1999•cell.comThe endoplasmic reticulum (ER) contains a variety of specialized proteins that interact with
secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi
apparatus. These accessory proteins might induce and/or stabilize a conformation that is
required for secretion competence or they might be directly involved in the sorting and
uptake of secretory proteins into Golgi-bound vesicles. Recent efforts have aimed to identify
and characterize the role of several of these substrate-specific accessory proteins.
secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi
apparatus. These accessory proteins might induce and/or stabilize a conformation that is
required for secretion competence or they might be directly involved in the sorting and
uptake of secretory proteins into Golgi-bound vesicles. Recent efforts have aimed to identify
and characterize the role of several of these substrate-specific accessory proteins.
Abstract
The endoplasmic reticulum (ER) contains a variety of specialized proteins that interact with secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi apparatus. These accessory proteins might induce and/or stabilize a conformation that is required for secretion competence or they might be directly involved in the sorting and uptake of secretory proteins into Golgi-bound vesicles. Recent efforts have aimed to identify and characterize the role of several of these substrate-specific accessory proteins.
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