[HTML][HTML] 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death
K Ozawa, K Kuwabara, M Tamatani, K Takatsuji… - Journal of Biological …, 1999 - ASBMB
To determine the contribution of 150-kDa oxygen-regulated protein (ORP150) to cellular
processes underlying adaptation to hypoxia, a cell line stably transfected to overexpress
ORP150 antisense RNA was created. In human embryonic kidney (HEK) cells stably
overexpressing ORP150 antisense RNA, ORP150 antigen and transcripts were suppressed
to low levels in normoxia and hypoxia, whereas wild-type cells showed induction of ORP150
with oxygen deprivation. Inhibition of ORP150 in antisense transfectants was selective, as …
processes underlying adaptation to hypoxia, a cell line stably transfected to overexpress
ORP150 antisense RNA was created. In human embryonic kidney (HEK) cells stably
overexpressing ORP150 antisense RNA, ORP150 antigen and transcripts were suppressed
to low levels in normoxia and hypoxia, whereas wild-type cells showed induction of ORP150
with oxygen deprivation. Inhibition of ORP150 in antisense transfectants was selective, as …