Marked, sustained expression of a novel 150-kDa oxygen-regulated stress protein, in severely ischemic mouse neurons

K Matsushita, T Matsuyama, H Nishimura… - Molecular brain …, 1998 - Elsevier
The 150-kDa oxygen-regulated protein (ORP150) first was described with reference to the
central nervous system in cultured astrocytes subjected to dense hypoxia. Subsequently its
transcript was found in macrophages within human aortic atherosclerotic plaques,
suggesting a role in protecting cells under hypoxic stress. In a mouse model of permanent
focal brain ischemia, we aimed to elucidate the constitutive cellular localization in vivo of
ORP150 in the central nervous system as well as the sequential alteration in its mRNA and …