The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid …
Hepatocytes from hypothyroid rats respire more slowly than those from control animals; cells
from hyperthyroid rats respire faster. We have identified the blocks of reactions whose
kinetics are significantly affected by thyroid hormones and have quantified the contribution of
flux through different blocks of energy-dissipating reactions to the altered oxygen
consumption. In cells from hypothyroid rats compared with littermate euthyroid controls,
there were significant kinetic effects on non-mitochondrial oxygen consumption reactions …
from hyperthyroid rats respire faster. We have identified the blocks of reactions whose
kinetics are significantly affected by thyroid hormones and have quantified the contribution of
flux through different blocks of energy-dissipating reactions to the altered oxygen
consumption. In cells from hypothyroid rats compared with littermate euthyroid controls,
there were significant kinetic effects on non-mitochondrial oxygen consumption reactions …