[HTML][HTML] Reconstitution, identification, and purification of the rat liver golgi membrane GDP-fucose transporter
L Puglielli, CB Hirschberg - Journal of Biological Chemistry, 1999 - ASBMB
Glycosylation of glycoproteins, proteoglycans, and glycolipids occurring in the Golgi
apparatus requires the translocation of nucleotide sugars from the cytosol into the lumen of
the Golgi. Translocation is mediated by specific nucleotide sugar transporters, integral Golgi
membrane proteins that regulate the above glycosylation reactions. A defect in GDP-fucose
transport into the lumen of the Golgi apparatus has been recently identified in a patient
affected by leukocyte adhesion deficiency type II syndrome (Lubke, T., Marquardt, T., von …
apparatus requires the translocation of nucleotide sugars from the cytosol into the lumen of
the Golgi. Translocation is mediated by specific nucleotide sugar transporters, integral Golgi
membrane proteins that regulate the above glycosylation reactions. A defect in GDP-fucose
transport into the lumen of the Golgi apparatus has been recently identified in a patient
affected by leukocyte adhesion deficiency type II syndrome (Lubke, T., Marquardt, T., von …