Glucose toxicity: the implications of hyperglycemia in the pathophysiology of diabetes mellitus.
L Rossetti - Clinical and Investigative Medicine. Medecine Clinique …, 1995 - europepmc.org
L Rossetti
Clinical and Investigative Medicine. Medecine Clinique et Experimentale, 1995•europepmc.orgNon-insulin-dependent diabetes mellitus (NIDDM) results from a disruption of normal
glucose homeostasis, primarily insulin secretion and hepatic and peripheral insulin action.
However, chronic hyperglycemia has been shown in animal models to contribute to
impaired insulin secretion as well as to peripheral insulin resistance. Consequently,
stringent control measures aimed at ameliorating chronically elevated blood glucose levels
may help lessen the cellular" toxic" effect of hyperglycemia.
glucose homeostasis, primarily insulin secretion and hepatic and peripheral insulin action.
However, chronic hyperglycemia has been shown in animal models to contribute to
impaired insulin secretion as well as to peripheral insulin resistance. Consequently,
stringent control measures aimed at ameliorating chronically elevated blood glucose levels
may help lessen the cellular" toxic" effect of hyperglycemia.
Non-insulin-dependent diabetes mellitus (NIDDM) results from a disruption of normal glucose homeostasis, primarily insulin secretion and hepatic and peripheral insulin action. However, chronic hyperglycemia has been shown in animal models to contribute to impaired insulin secretion as well as to peripheral insulin resistance. Consequently, stringent control measures aimed at ameliorating chronically elevated blood glucose levels may help lessen the cellular" toxic" effect of hyperglycemia.
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