[HTML][HTML] Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase
K Wiegmann, R Schwandner, O Krut, WC Yeh… - Journal of Biological …, 1999 - ASBMB
The generation of mice strains deficient for select members of the signaling complex of the
55-kDa tumor necrosis factor receptor (TNF-R55) has allowed the assignment of specific
cellular responses to distinct TNF-R55-associated proteins. In particular, the TNF-R55-
associated protein FADD seems to be responsible for recruitment and subsequent activation
of caspase 8. In this report we demonstrate the requirement of FADD for TNF-induced
activation of endosomal acid sphingomyelinase (A-SMase). In primary embryonic fibroblasts …
55-kDa tumor necrosis factor receptor (TNF-R55) has allowed the assignment of specific
cellular responses to distinct TNF-R55-associated proteins. In particular, the TNF-R55-
associated protein FADD seems to be responsible for recruitment and subsequent activation
of caspase 8. In this report we demonstrate the requirement of FADD for TNF-induced
activation of endosomal acid sphingomyelinase (A-SMase). In primary embryonic fibroblasts …