[HTML][HTML] Molecular basis for ADP-induced platelet activation: I. Evidence for three distinct ADP receptors on human platelets
JL Daniel, C Dangelmaier, J Jin, B Ashby… - Journal of Biological …, 1998 - ASBMB
Acting through cell surface receptors, ADP activates platelets resulting in shape change,
aggregation, thromboxane A 2 production, and release of granule contents. ADP also
causes a number of intracellular events including inhibition of adenylyl cyclase, mobilization
of calcium from intracellular stores, and rapid calcium influx in platelets. However, the
receptors that transduce these events remain unidentified and their molecular mechanisms
of action have not been elucidated. The receptor responsible for the actions of ADP on …
aggregation, thromboxane A 2 production, and release of granule contents. ADP also
causes a number of intracellular events including inhibition of adenylyl cyclase, mobilization
of calcium from intracellular stores, and rapid calcium influx in platelets. However, the
receptors that transduce these events remain unidentified and their molecular mechanisms
of action have not been elucidated. The receptor responsible for the actions of ADP on …