A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia
E Bunnell, M Lynn, K Habet, A Neumann… - Critical care …, 2000 - journals.lww.com
Background Endotoxin (lipopolysaccharide [LPS]) has been associated with sepsis and the
high mortality rate seen in septic shock. The administration of a small amount of LPS to
healthy subjects produces a mild syndrome qualitatively similar to that seen in clinical
sepsis. We used this model to test the efficacy of an endotoxin antagonist, E5531, in
blocking this LPS-induced syndrome. Methods In a placebo-controlled, double-blind study,
we randomly assigned 32 healthy volunteers to four sequential groups (100, 250, 500, or …
high mortality rate seen in septic shock. The administration of a small amount of LPS to
healthy subjects produces a mild syndrome qualitatively similar to that seen in clinical
sepsis. We used this model to test the efficacy of an endotoxin antagonist, E5531, in
blocking this LPS-induced syndrome. Methods In a placebo-controlled, double-blind study,
we randomly assigned 32 healthy volunteers to four sequential groups (100, 250, 500, or …