TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study
Lenercept Multiple Sclerosis Study Group and The … - Neurology, 1999 - AAN Enterprises
Objective: A double-blind, placebo-controlled phase II study was conducted in 168 patients,
most with relapsing-remitting MS, to evaluate whether lenercept would reduce new lesions
on MRI. Background: Tumor necrosis factor (TNF) has been implicated in MS pathogenesis,
has been identified in active MS lesions, is toxic to oligodendrocytes in vitro, and worsens
the severity of experimental allergic encephalomyelitis (EAE) in animals. Lenercept, a
recombinant TNF receptor p55 immunoglobulin fusion protein (sTNFR-IgG p55), protects …
most with relapsing-remitting MS, to evaluate whether lenercept would reduce new lesions
on MRI. Background: Tumor necrosis factor (TNF) has been implicated in MS pathogenesis,
has been identified in active MS lesions, is toxic to oligodendrocytes in vitro, and worsens
the severity of experimental allergic encephalomyelitis (EAE) in animals. Lenercept, a
recombinant TNF receptor p55 immunoglobulin fusion protein (sTNFR-IgG p55), protects …
[CITATION][C] TNF neutralization in MS-Results of a randomized, placebo-controlled multicenter study
B Arnason, G Jacobs, M Hanlon, B Clay, A Noronha… - Neurology, 1999 - ora.ox.ac.uk
TNF neutralization in MS - Results of a randomized, placebo-controlled multicenter study - ORA
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