[HTML][HTML] α2A-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels
IMLW Keularts, RMA van Gorp, MAH Feijge… - Journal of Biological …, 2000 - ASBMB
α 2A-Adrenergic receptor-mediated Ca 2+ signaling and integrin α IIb β 3 exposure were
investigated in human platelets under conditions where indirect, thromboxane-or ADP-
mediated effects were absent. The α 2-adrenergic receptor agonists, UK14304 and
epinephrine (EPI), were unable to raise cytosolic levels of inositol 1, 4, 5-trisphosphate (InsP
3) or Ca 2+ but potentiated the [Ca 2+] i rises evoked by other agonists that act through
stimulation of phospholipase C (thrombin or platelet-activating factor) or stimulation of Ca 2+ …
investigated in human platelets under conditions where indirect, thromboxane-or ADP-
mediated effects were absent. The α 2-adrenergic receptor agonists, UK14304 and
epinephrine (EPI), were unable to raise cytosolic levels of inositol 1, 4, 5-trisphosphate (InsP
3) or Ca 2+ but potentiated the [Ca 2+] i rises evoked by other agonists that act through
stimulation of phospholipase C (thrombin or platelet-activating factor) or stimulation of Ca 2+ …