[HTML][HTML] Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium: novel role of mitogen …
MA Gijón, DM Spencer, AR Siddiqi… - Journal of biological …, 2000 - ASBMB
The 85-kDa cytosolic phospholipase A 2 (cPLA 2) mediates agonist-induced arachidonic
acid release and eicosanoid production. Calcium and phosphorylation on Ser-505 by
mitogen-activated protein kinases (MAPKs) regulate cPLA 2. Arachidonic acid release and
eicosanoid production induced by stimuli that do (A23187, zymosan) or do not (phorbol
myristate acetate (PMA), okadaic acid) mobilize calcium were quantitatively suppressed in
cPLA 2-deficient mouse peritoneal macrophages. The contribution of MAPKs to cPLA 2 …
acid release and eicosanoid production. Calcium and phosphorylation on Ser-505 by
mitogen-activated protein kinases (MAPKs) regulate cPLA 2. Arachidonic acid release and
eicosanoid production induced by stimuli that do (A23187, zymosan) or do not (phorbol
myristate acetate (PMA), okadaic acid) mobilize calcium were quantitatively suppressed in
cPLA 2-deficient mouse peritoneal macrophages. The contribution of MAPKs to cPLA 2 …