[HTML][HTML] Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase
JH Capdevila, JR Falck, RC Harris - Journal of lipid research, 2000 - ASBMB
The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways
and as members of the arachidonate metabolic cascade. The characterization of the potent
biological activities associated with several of the cytochrome P450-derived eicosanoids
suggested new and important functional roles for these enzymes in cellular, organ, and body
physiology, including the control of vascular reactivity and systemic blood pressures. Past …
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways
and as members of the arachidonate metabolic cascade. The characterization of the potent
biological activities associated with several of the cytochrome P450-derived eicosanoids
suggested new and important functional roles for these enzymes in cellular, organ, and body
physiology, including the control of vascular reactivity and systemic blood pressures. Past …