[HTML][HTML] Phosphorylation of the thromboxane receptor α, the predominant isoform expressed in human platelets
A Habib, GA FitzGerald, J Maclouf - Journal of Biological Chemistry, 1999 - ASBMB
A single gene encodes the human thromboxane receptor (TP), of which there are two
identified splice variants, α and β. Both isoforms are rapidly phosphorylated in response to
thromboxane agonists when overexpressed in human embryonic kidney 293 cells; this
phenomenon is only slightly altered by inhibitors of protein kinase C. Pharmacological
studies have defined two classes of TP in human platelets; sites that bind the agonist I-BOP
with high affinity support platelet shape change. Low affinity sites, which irreversibly bind the …
identified splice variants, α and β. Both isoforms are rapidly phosphorylated in response to
thromboxane agonists when overexpressed in human embryonic kidney 293 cells; this
phenomenon is only slightly altered by inhibitors of protein kinase C. Pharmacological
studies have defined two classes of TP in human platelets; sites that bind the agonist I-BOP
with high affinity support platelet shape change. Low affinity sites, which irreversibly bind the …