[HTML][HTML] Identification of two major F2 isoprostanes, 8, 12-iso-and 5-epi-8, 12-iso-isoprostane F2α-VI, in human urine
JA Lawson, H Li, J Rokach, M Adiyaman… - Journal of Biological …, 1998 - ASBMB
Isoprostanes (iPs) are nonenzymatic, free radical-derived compounds isomeric with
enzymatically formed eicosanoids such as prostaglandins, leukotrienes, and thromboxanes.
One group formed by the auto-oxidation of arachidonic acid, the F 2-iPs, consists of four
classes of isomers of prostaglandin F 2α (PGF 2α). They are relatively abundant in human
urine. This fact, along with their chemical stability and excellent characteristics for
quantitation by gas chromatography/mass spectrometry, has made them attractive indices of …
enzymatically formed eicosanoids such as prostaglandins, leukotrienes, and thromboxanes.
One group formed by the auto-oxidation of arachidonic acid, the F 2-iPs, consists of four
classes of isomers of prostaglandin F 2α (PGF 2α). They are relatively abundant in human
urine. This fact, along with their chemical stability and excellent characteristics for
quantitation by gas chromatography/mass spectrometry, has made them attractive indices of …