Rapid and slow hydroxylators of seminal E prostaglandins

EH Oliw - Biochimica et Biophysica Acta (BBA)-Lipids and Lipid …, 1988 - Elsevier
Human seminal fluid contains prostaglandin (PG) E 1, PGE 2, 19-hydroxy-PGE 1 and 19-
hydroxy-PGE 2 in large and variable amounts. 19-Hydroxy-PGE 1 and 19-hydroxy-PGE 2
are formed from PGE 1 and PGE 2 by prostaglandin 19-hydroxylase, a cytochrome P-450
enzyme, in seminal vesicles. The hypothesis that genetic polymorphism of this enzyme
might contribute to the variable concentrations of PGE 1, PGE 2, 19-hydroxy-PGE 1 and 19-
hydroxy-PGE 2, was examined by analysis of seminal fluid of 40 normal men. E …