[HTML][HTML] Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2
KR Kozak, SW Rowlinson, LJ Marnett - Journal of Biological Chemistry, 2000 - ASBMB
Cyclooxygenases (COX) play an important role in lipid signaling by oxygenating arachidonic
acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases
exist which differ in tissue distribution and regulation but otherwise carry out identical
chemical functions. The neutral arachidonate derivative, 2-arachidonylglycerol (2-AG), is
one of two described endocannabinoids and appears to be a ligand for both the central
(CB1) and peripheral (CB2) cannabinoid receptors. Here we report that 2-AG is a substrate …
acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases
exist which differ in tissue distribution and regulation but otherwise carry out identical
chemical functions. The neutral arachidonate derivative, 2-arachidonylglycerol (2-AG), is
one of two described endocannabinoids and appears to be a ligand for both the central
(CB1) and peripheral (CB2) cannabinoid receptors. Here we report that 2-AG is a substrate …