[HTML][HTML] Cross-talk between Janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-α (PPARα) …

YC Zhou, DJ Waxman - Journal of Biological Chemistry, 1999 - ASBMB
Hepatic peroxisome proliferation induced by structurally diverse non-genotoxic carcinogens
is mediated by the nuclear receptor peroxisome proliferator-activated receptor (PPARα) and
can be inhibited by growth hormone (GH). GH-stimulated Janus kinase-signal transducer
and activator of transcription 5b (JAK2/STAT5b) signaling and the PPAR activation pathway
were reconstituted in COS-1 cells to investigate the mechanism for this GH inhibitory effect.
Activation of STAT5b signaling by either GH or prolactin inhibited, by up to 80–85%, ligand …