[HTML][HTML] Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor α by phosphorylation of a ligand-independent trans-activating …
CE Juge-Aubry, E Hammar, C Siegrist-Kaiser… - Journal of Biological …, 1999 - ASBMB
The peroxisome proliferator-activated receptors (PPARs) are a subgroup of nuclear
receptors activated by fatty acids and eicosanoids. In addition, they are subject to
phosphorylation by insulin, resulting in the activation of PPARα, while inhibiting PPARγ
under certain conditions. However, it was hitherto unclear whether the stimulatory effect of
insulin on PPARα was direct and by which mechanism it occurs. We now demonstrate that
amino acids 1–92 of hPPARα contain an activation function (AF)-1-like domain, which is …
receptors activated by fatty acids and eicosanoids. In addition, they are subject to
phosphorylation by insulin, resulting in the activation of PPARα, while inhibiting PPARγ
under certain conditions. However, it was hitherto unclear whether the stimulatory effect of
insulin on PPARα was direct and by which mechanism it occurs. We now demonstrate that
amino acids 1–92 of hPPARα contain an activation function (AF)-1-like domain, which is …