The isoprenoids farnesol and juvenile hormone III (JH), metabolites of the cholesterol
biosynthetic pathway, have been shown to stimulate fetal epidermal development in rodents.
In this study we determined whether this effect might be attributed to a direct induction of
keratinocytes differentiation and examined the mechanisms responsible for these effects.
Rates of cornified envelope formation, a marker of keratinocyte terminal differentiation, as
well as protein and mRNA levels of two proteins required for cornified envelope formation …