Direct vascular effects of HMG-CoA reductase inhibitors
S Bellosta, F Bernini, N Ferri, P Quarato, M Canavesi… - Atherosclerosis, 1998 - Elsevier
Several studies have demonstrated that any beneficial effect of 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events are linked to their
hypocholesterolemic properties. However, since mevalonic acid (MVA), the product of the
enzyme reaction, is the precursor of numerous metabolites, inhibition of HMG-CoA
reductase has the potential to result in pleiotropic effects. MVA and other intermediates of
cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important …
coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events are linked to their
hypocholesterolemic properties. However, since mevalonic acid (MVA), the product of the
enzyme reaction, is the precursor of numerous metabolites, inhibition of HMG-CoA
reductase has the potential to result in pleiotropic effects. MVA and other intermediates of
cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important …