[HTML][HTML] Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq …
F Lesage, C Terrenoire, G Romey… - Journal of Biological …, 2000 - ASBMB
Mechano-sensitive and fatty acid-activated K+ belong to the structural class of K+ channel
with two pore domains. Here, we report the isolation and the characterization of a novel
member of this family. This channel, called TREK2, is closely related to TREK1 (78% of
homology). Its gene is located on chromosome 14q31. TREK2 is abundantly expressed in
pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. In the
central nervous system, TREK2 has a widespread distribution with the highest levels of …
with two pore domains. Here, we report the isolation and the characterization of a novel
member of this family. This channel, called TREK2, is closely related to TREK1 (78% of
homology). Its gene is located on chromosome 14q31. TREK2 is abundantly expressed in
pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. In the
central nervous system, TREK2 has a widespread distribution with the highest levels of …