[HTML][HTML] Essential Requirement of Cytosolic Phospholipase A2for Activation of the H+ Channel in Phagocyte-like Cells
A Lowenthal, R Levy - Journal of Biological Chemistry, 1999 - ASBMB
The NADPH oxidase-producing superoxide is the major mechanism by which phagocytes
kill invading pathogens. We previously established a model of cytosolic phospholipase A 2
(cPLA 2)-deficient differentiated PLB-985 cells (PLB-D cells) and demonstrated that cPLA 2-
generated arachidonic acid (AA) is essential for NADPH oxidase activation (Dana, R., Leto,
T., Malech, H., and Levy, R.(1998) J. Biol. Chem. 273, 441–445). In the present study, we
used this model to determine the physiological role of cPLA 2 in the regulation of both the …
kill invading pathogens. We previously established a model of cytosolic phospholipase A 2
(cPLA 2)-deficient differentiated PLB-985 cells (PLB-D cells) and demonstrated that cPLA 2-
generated arachidonic acid (AA) is essential for NADPH oxidase activation (Dana, R., Leto,
T., Malech, H., and Levy, R.(1998) J. Biol. Chem. 273, 441–445). In the present study, we
used this model to determine the physiological role of cPLA 2 in the regulation of both the …