Correlates of protection in HIV infection and the progression of HIV infection to AIDS
M Clerici, GM Shearer - Immunology letters, 1996 - Elsevier
Exposure to human immunodeficency virus (HIV) can result in HIV infection which is defined
by seroconversion and the detection of HIV-specific antibodies. Nevertheless, in every
cohort at risk for HIV infection, individuals are present in whom seroconversion is not
observed despite multiple documented exposures to HIV. Recent studies have shown that
HIV-specific T-lymphocytes are present in the peripheral blood of these HIV-exposed
seronegative individuals, suggesting that cell-mediated immunity (CMI) could have a …
by seroconversion and the detection of HIV-specific antibodies. Nevertheless, in every
cohort at risk for HIV infection, individuals are present in whom seroconversion is not
observed despite multiple documented exposures to HIV. Recent studies have shown that
HIV-specific T-lymphocytes are present in the peripheral blood of these HIV-exposed
seronegative individuals, suggesting that cell-mediated immunity (CMI) could have a …