[HTML][HTML] Homocyst (e) ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
GR Upchurch, GN Welch, AJ Fabian… - Journal of Biological …, 1997 - ASBMB
Hyperhomocyst (e) inemia is believed to injure endothelial cells in vivo through a number of
mechanisms, including the generation of hydrogen peroxide (H 2 O 2). Earlier in vitro
studies demonstrated that homocyst (e) ine (Hcy) decreases the biological activity of
endothelium-derived relaxing factor and that this decrease can be reversed by preventing
the generation of hydrogen peroxide. Here we show that Hcy treatment of bovine aortic
endothelial cells leads to a dose-dependent decrease in NO x (p= 0.001 by one-way …
mechanisms, including the generation of hydrogen peroxide (H 2 O 2). Earlier in vitro
studies demonstrated that homocyst (e) ine (Hcy) decreases the biological activity of
endothelium-derived relaxing factor and that this decrease can be reversed by preventing
the generation of hydrogen peroxide. Here we show that Hcy treatment of bovine aortic
endothelial cells leads to a dose-dependent decrease in NO x (p= 0.001 by one-way …