[HTML][HTML] Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
M Amemiya-Kudo, H Shimano, T Yoshikawa… - Journal of Biological …, 2000 - ASBMB
Recent data suggest that sterol regulatory-binding protein (SREBP)-1c plays a key role in
the transcriptional regulation of different lipogenic genes mediating lipid synthesis as a key
regulator of fuel metabolism. SREBP-1c regulates its downstream genes by changing its
own mRNA level, which led us to sequence and analyze the promoter region of the mouse
SREBP-1c gene. A cluster of putative binding sites of several transcription factors composed
of an NF-Y site, an E-box, a sterol-regulatory element 3, and an Sp1 site were located at− 90 …
the transcriptional regulation of different lipogenic genes mediating lipid synthesis as a key
regulator of fuel metabolism. SREBP-1c regulates its downstream genes by changing its
own mRNA level, which led us to sequence and analyze the promoter region of the mouse
SREBP-1c gene. A cluster of putative binding sites of several transcription factors composed
of an NF-Y site, an E-box, a sterol-regulatory element 3, and an Sp1 site were located at− 90 …