[HTML][HTML] Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene …
S Ye, P Eriksson, A Hamsten, M Kurkinen… - Journal of Biological …, 1996 - ASBMB
There is a common polymorphism in the promoter sequence of the human stromelysin-1
gene, with one allele having a run of six adenosines (6A) and the other five adenosines
(5A). We have previously reported, in a 3-year follow-up study of patients with coronary
atherosclerosis, that those patients who are homozygous for the 6A allele show a more rapid
progression of the disease. In this study, we have investigated whether the 5A/6A promoter
polymorphism plays a role in the regulation of stromelysin-1 gene expression. In transient …
gene, with one allele having a run of six adenosines (6A) and the other five adenosines
(5A). We have previously reported, in a 3-year follow-up study of patients with coronary
atherosclerosis, that those patients who are homozygous for the 6A allele show a more rapid
progression of the disease. In this study, we have investigated whether the 5A/6A promoter
polymorphism plays a role in the regulation of stromelysin-1 gene expression. In transient …