Low density lipoproteins bind more to type I and III collagens by negative charge-dependent mechanisms than to type IV and V collagens
S Jimi, N Sakata, A Matunaga, S Takebayashi - Atherosclerosis, 1994 - Elsevier
The accumulation of low density lipoprotein (LDL) in the arterial intima is an important
characteristic of atherosclerosis. We investigated the mechanisms by which LDL binds to
different types of collagen. The binding activities of 125 I-labeled human native LDL (nLDL)
and copper-oxidized LDL (oxLDL) with different collagen gels prepared in type I collagen-
based mixtures with types I, III, IV and V (I+ I, I+ III, I+ IV and I+ V, respectively) were
examined. A concentration of 20 μg LDL protein/150 μg collagen/well was used. The …
characteristic of atherosclerosis. We investigated the mechanisms by which LDL binds to
different types of collagen. The binding activities of 125 I-labeled human native LDL (nLDL)
and copper-oxidized LDL (oxLDL) with different collagen gels prepared in type I collagen-
based mixtures with types I, III, IV and V (I+ I, I+ III, I+ IV and I+ V, respectively) were
examined. A concentration of 20 μg LDL protein/150 μg collagen/well was used. The …