Elevated homocysteine levels have been suggested to contribute to various pathological
states of the brain. However, the basic mechanisms underlying homocysteine-induced
neurotoxicity have not yet been fully elucidated. In the present series of experiments, we
investigated the effect of homocysteine on mRNA levels of genes coding for cytoplasmic-or
endoplasmic reticulum-resident stress proteins. Primary neuronal cell cultures were
exposed to different homocysteine levels for 1–24 h. Cell injury was evaluated using the …