The ER-overload response: activation of NF-κB
HL Pahl, PA Baeuerle - Trends in biochemical sciences, 1997 - cell.com
HL Pahl, PA Baeuerle
Trends in biochemical sciences, 1997•cell.comVarious conditions that perturb the function of the endoplasmic reticulum (ER) were recently
shown to activate the transcription factor NF-κB. Activation of NF-κB is caused by the
accumulation of proteins in the ER membrane, a condition we have called ER overload.
Both the release of Ca 2+ from the ER and the subsequent production of reactive oxygen
intermediates are required for ER-overload-mediated NF-κB activation. This novel
intracellular signal transduction pathway might be important in antiviral defense and play a …
shown to activate the transcription factor NF-κB. Activation of NF-κB is caused by the
accumulation of proteins in the ER membrane, a condition we have called ER overload.
Both the release of Ca 2+ from the ER and the subsequent production of reactive oxygen
intermediates are required for ER-overload-mediated NF-κB activation. This novel
intracellular signal transduction pathway might be important in antiviral defense and play a …
Abstract
Various conditions that perturb the function of the endoplasmic reticulum (ER) were recently shown to activate the transcription factor NF-κB. Activation of NF-κB is caused by the accumulation of proteins in the ER membrane, a condition we have called ER overload. Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-κB activation. This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.
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