[HTML][HTML] Divergent Mechanisms for Homologous Desensitization of p21ras by Insulin and Growth Factors (∗)
JK Klarlund, AD Cherniack, MP Czech - Journal of Biological Chemistry, 1995 - ASBMB
Previous work suggested that desensitization of p21 ras in response to growth factors such
as epidermal growth factor (EGF) results from receptor down-regulation. Here we show that
p21 ras is desensitized by insulin in 3T3-L1 adipocytes in the continued presence of
activated insulin receptors, while loss of epidermal growth factor and platelet-derived growth
factor (PDGF) receptors in response to their ligands correlates with p21 ras desensitization.
Furthermore, elevated amounts of Grb2/Shc complexes persisted throughout p21 ras …
as epidermal growth factor (EGF) results from receptor down-regulation. Here we show that
p21 ras is desensitized by insulin in 3T3-L1 adipocytes in the continued presence of
activated insulin receptors, while loss of epidermal growth factor and platelet-derived growth
factor (PDGF) receptors in response to their ligands correlates with p21 ras desensitization.
Furthermore, elevated amounts of Grb2/Shc complexes persisted throughout p21 ras …