[HTML][HTML] Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase …
F Weber, K Fukino, T Sawada, N Williams… - British journal of …, 2005 - nature.com
F Weber, K Fukino, T Sawada, N Williams, K Sweet, RM Brena, C Plass, T Caldes, GL Mutter…
British journal of cancer, 2005•nature.comOrgan-specific differences in epidermal growth factor receptor (EGFR) mutational spectra
and frequencies were found in lung cancer and sporadic and BRCA 1/2-related breast
cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of
these invasive breast carcinomas. Those organ-specific mutational spectra and potential
targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
and frequencies were found in lung cancer and sporadic and BRCA 1/2-related breast
cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of
these invasive breast carcinomas. Those organ-specific mutational spectra and potential
targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
Abstract
Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA 1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
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