Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics

CM Ulrich, J Bigler, JD Potter - Nature Reviews Cancer, 2006 - nature.com
CM Ulrich, J Bigler, JD Potter
Nature Reviews Cancer, 2006nature.com
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) show indisputable
promise as chemopreventive agents. Possible targets include cancers of the colon, stomach,
breast and lung. However, recent studies raise concern about potential cardiovascular
toxicity associated with the use of NSAIDs that specifically target the enzyme
cyclooxygenase 2. These findings, and others that show that inherited genetic
characteristics might determine preventive success, argue for new strategies that are …
Abstract
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) show indisputable promise as chemopreventive agents. Possible targets include cancers of the colon, stomach, breast and lung. However, recent studies raise concern about potential cardiovascular toxicity associated with the use of NSAIDs that specifically target the enzyme cyclooxygenase 2. These findings, and others that show that inherited genetic characteristics might determine preventive success, argue for new strategies that are tailored to individual medical history and genetic make-up.
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