[HTML][HTML] The activation state of αvβ3Regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved Osteopontin
O Helluin, C Chan, G Vilaire, S Mousa… - Journal of Biological …, 2000 - ASBMB
Cleavage of osteopontin by thrombin has been reported to enhance cell adhesion. We
asked whether thrombin could regulate the α v β 3-mediated adhesion of platelets and B
lymphocytes to this substrate. Although there was no difference in the extent or the avidity of
thrombin-and ADP-stimulated platelet adhesion to intact or thrombin-cleaved human
osteopontin, both the extent and avidity of phorbol ester-stimulated B cell adhesion to
thrombin-cleaved osteopontin was significantly increased. Thus, these data suggest that the …
asked whether thrombin could regulate the α v β 3-mediated adhesion of platelets and B
lymphocytes to this substrate. Although there was no difference in the extent or the avidity of
thrombin-and ADP-stimulated platelet adhesion to intact or thrombin-cleaved human
osteopontin, both the extent and avidity of phorbol ester-stimulated B cell adhesion to
thrombin-cleaved osteopontin was significantly increased. Thus, these data suggest that the …