[HTML][HTML] Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

Y Wang, S Huang, VP Sah, J Ross, JH Brown… - Journal of Biological …, 1998 - ASBMB
p38 mitogen-activated protein (MAP) kinase activities were significantly increased in mouse
hearts after chronic transverse aortic constriction, coincident with the onset of ventricular
hypertrophy. Infection of cardiomyocytes with adenoviral vectors expressing upstream
activators for the p38 kinases, activated mutants of MAP kinase kinase 3b (E)(MKK3bE) and
MAP kinase kinase 6b (E)(MKK6bE), elicited characteristic hypertrophic responses,
including an increase in cell size, enhanced sarcomeric organization, and elevated atrial …