[HTML][HTML] Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions
K Ishiguro, K Kadomatsu, T Kojima… - Journal of Biological …, 2000 - ASBMB
Two domains of fibronectin deliver two different but cooperative signals required for focal
adhesion formation. The signal from the cell-binding domain is mediated by integrins,
whereas the signal from the heparin-binding domain is recognized by heparan sulfate
proteoglycans, of which syndecan-4 has been hypothesized to be involved in focal adhesion
formation. We generated mice deficient in syndecan-4 to study its role directly. Even in
fibroblasts from syndecan-4-deficient mice, focal adhesions were formed, and actin fibers …
adhesion formation. The signal from the cell-binding domain is mediated by integrins,
whereas the signal from the heparin-binding domain is recognized by heparan sulfate
proteoglycans, of which syndecan-4 has been hypothesized to be involved in focal adhesion
formation. We generated mice deficient in syndecan-4 to study its role directly. Even in
fibroblasts from syndecan-4-deficient mice, focal adhesions were formed, and actin fibers …