[HTML][HTML] Thrombspondin acts via integrin-associated protein to activate the platelet integrin αIIbβ3
J Chung, AG Gao, WA Frazier - Journal of Biological Chemistry, 1997 - ASBMB
Integrin-associated protein (IAP or CD47) is a receptor for the cell/platelet-binding domain
(CBD) of thrombospondin-1 (TS1), the most abundant protein of platelet α granules.
Although it associates with αIIbβ3, IAP has no known function in platelets. TS1, the CBD, and
an IAP agonist peptide (4N1K) from the CBD of TS1 activate the platelet integrin αIIbβ3,
resulting in platelet spreading on immobilized fibrinogen, stimulation of platelet aggregation,
and enhanced tyrosine phosphorylation of focal adhesion kinase. Furthermore, 4N1K …
(CBD) of thrombospondin-1 (TS1), the most abundant protein of platelet α granules.
Although it associates with αIIbβ3, IAP has no known function in platelets. TS1, the CBD, and
an IAP agonist peptide (4N1K) from the CBD of TS1 activate the platelet integrin αIIbβ3,
resulting in platelet spreading on immobilized fibrinogen, stimulation of platelet aggregation,
and enhanced tyrosine phosphorylation of focal adhesion kinase. Furthermore, 4N1K …
