Control mechanisms of gluconeogenesis and ketogenesis: I. Effects of oleate on gluconeogenesis in perfused rat liver
JR Williamson, ET Browning, R Scholz - Journal of Biological Chemistry, 1969 - ASBMB
The effects of oleate (1.0 to 1.5 mM) were studied in livers from fasted rats perfused with
alanine (5 to 10 mM), L (+)-lactate (8 to 12 mM), pyruvate (1.5 to 2.0 mM), or
dihydroxyacetone (10 mM) as gluconeogenic precursors. Rates of glucose production in
control livers perfused with alanine, lactate, or pyruvate were 60, 120, and 95 µmoles p er
100 g, body weight, per hour, respectively. Oleate increased these rates to 132, 250, and
194 µmoles per 100 g, body weight, per hour with the three substrates. With lactate as …
alanine (5 to 10 mM), L (+)-lactate (8 to 12 mM), pyruvate (1.5 to 2.0 mM), or
dihydroxyacetone (10 mM) as gluconeogenic precursors. Rates of glucose production in
control livers perfused with alanine, lactate, or pyruvate were 60, 120, and 95 µmoles p er
100 g, body weight, per hour, respectively. Oleate increased these rates to 132, 250, and
194 µmoles per 100 g, body weight, per hour with the three substrates. With lactate as …