C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis
SA Schreyer, DL Wilson, RC LeBoeuf - Atherosclerosis, 1998 - Elsevier
Non-insulin-dependent diabetes mellitus (NIDDM) is a major risk factor for the development
of atherosclerosis in humans. The development of an animal model that displays
accelerated atherosclerosis associated with NIDDM will aid in elucidating the mechanisms
that associate these disorders. C57BL/6 mice may provide such a model system. This strain
becomes obese, hyperglycemic and insulin resistant when fed a high fat diet (diabetogenic
diet) and is susceptible to atherosclerotic lesion development when fed a separate high fat …
of atherosclerosis in humans. The development of an animal model that displays
accelerated atherosclerosis associated with NIDDM will aid in elucidating the mechanisms
that associate these disorders. C57BL/6 mice may provide such a model system. This strain
becomes obese, hyperglycemic and insulin resistant when fed a high fat diet (diabetogenic
diet) and is susceptible to atherosclerotic lesion development when fed a separate high fat …