TRAF6 is a signal transducer for interleukin-1
Z Cao, J Xiong, M Takeuchi, T Kurama, DV Goeddel - Nature, 1996 - nature.com
Z Cao, J Xiong, M Takeuchi, T Kurama, DV Goeddel
Nature, 1996•nature.comMANY cytokines signal through different cell-surface receptors to activate the transcription
factor NF-κB (ref. 1). Members of the TRAF protein family have been implicated in the
activation of NF-κB by the tumour-necrosis factor (TNF)-receptor superfamily2–5. Here we
report the identification of a new TRAF family member, designated TRAF6. When
overexpressed in human 293 cells, TRAF6 activates NF-κB. A dominant-negative mutant of
TRAF6 inhibits NF-κB activation signalled by interleukin-1 (IL-1) but not by TNF. IL-1 …
factor NF-κB (ref. 1). Members of the TRAF protein family have been implicated in the
activation of NF-κB by the tumour-necrosis factor (TNF)-receptor superfamily2–5. Here we
report the identification of a new TRAF family member, designated TRAF6. When
overexpressed in human 293 cells, TRAF6 activates NF-κB. A dominant-negative mutant of
TRAF6 inhibits NF-κB activation signalled by interleukin-1 (IL-1) but not by TNF. IL-1 …
Abstract
MANY cytokines signal through different cell-surface receptors to activate the transcription factor NF-κB (ref. 1). Members of the TRAF protein family have been implicated in the activation of NF-κB by the tumour-necrosis factor (TNF)-receptor superfamily2–5. Here we report the identification of a new TRAF family member, designated TRAF6. When overexpressed in human 293 cells, TRAF6 activates NF-κB. A dominant-negative mutant of TRAF6 inhibits NF-κB activation signalled by interleukin-1 (IL-1) but not by TNF. IL-1 treatment of 293 cells induces the association of TRAF6 with IRAK, a serine/threonine kinase that is rapidly recruited to the IL-1 receptor after IL-1 induction6. These findings indicate that TRAF proteins may function as signal transducers for distinct receptor families and that TRAF6 participates in IL-1 signalling.
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