Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes
BK Patterson, MA Czerniewski, J Andersson… - Clinical …, 1999 - Elsevier
HIV-1 transmission and disease progression is, in general, characterized by initial
predominance of macrophage tropic, non-syncytium-inducing strains followed by a switch to
T-cell tropic, syncytium-inducing strains. Using sensitive, quantitative kinetic RT-PCR, we
examined cytokine regulation of tropism-specific HIV-1 coreceptor expression in PBMCs
from HIV-1-seronegative individuals. Proinflammatory (TNF-α and IL-12) and type 1
cytokines (IFN-γ and IL-2) significantly upregulated CCR5 (wt allele) mRNA expression in …
predominance of macrophage tropic, non-syncytium-inducing strains followed by a switch to
T-cell tropic, syncytium-inducing strains. Using sensitive, quantitative kinetic RT-PCR, we
examined cytokine regulation of tropism-specific HIV-1 coreceptor expression in PBMCs
from HIV-1-seronegative individuals. Proinflammatory (TNF-α and IL-12) and type 1
cytokines (IFN-γ and IL-2) significantly upregulated CCR5 (wt allele) mRNA expression in …