Transforming growth factor-β1 induces extracellular matrix formation in glomerulonephritis
WA Border, E Ruoslahti - Cell Differentiation and Development, 1990 - Elsevier
Extracellular matrices can be important in disease. Glomerulonephritis is an inflammation of
the kidney that is characterized by the accumulation of extracellular matrix within the
damaged glomeruli. We have shown that transforming growth factor-β1 (TGF-β1) is unique
in regulating the production of proteoglycans and matrix glycoproteins by glomerular cells in
vitro. In an experimental model of glomerulonephritis in rats, we found increased
proteoglycan and fibronectin synthesis by cultured nephritic glomeruli, which was greatly …
the kidney that is characterized by the accumulation of extracellular matrix within the
damaged glomeruli. We have shown that transforming growth factor-β1 (TGF-β1) is unique
in regulating the production of proteoglycans and matrix glycoproteins by glomerular cells in
vitro. In an experimental model of glomerulonephritis in rats, we found increased
proteoglycan and fibronectin synthesis by cultured nephritic glomeruli, which was greatly …