CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
Nature immunology, 2000•nature.com
The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key
step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that
ligation of the C–C chemokine receptor (CCR) 5 can provide a major signal for the induction
of IL-12 synthesis by the CD8α+ subset of DC and that this pathway is important in
establishing interferon γ-dependent resistance to the protozoan parasite Toxoplasma gondii.
These findings support the concept that the early induction of chemokines by invading …
step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that
ligation of the C–C chemokine receptor (CCR) 5 can provide a major signal for the induction
of IL-12 synthesis by the CD8α+ subset of DC and that this pathway is important in
establishing interferon γ-dependent resistance to the protozoan parasite Toxoplasma gondii.
These findings support the concept that the early induction of chemokines by invading …
Abstract
The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C–C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8α+ subset of DC and that this pathway is important in establishing interferon γ-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.
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