[HTML][HTML] Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side …
N Huang, WL Miller - Journal of Biological Chemistry, 2000 - ASBMB
The cholesterol side-chain cleavage enzyme, cytochrome P450scc, initiates the
biosynthesis of all steroid hormones. Adrenal and gonadal strategies for P450scc gene
transcription are essentially identical and depend on the orphan nuclear receptor
steroidogenic factor-1, but the placental strategy for transcription of P450scc employs cis-
acting elements different from those used in the adrenal strategy and is independent of
steroidogenic factor-1. Because placental expression of P450scc is required for human …
biosynthesis of all steroid hormones. Adrenal and gonadal strategies for P450scc gene
transcription are essentially identical and depend on the orphan nuclear receptor
steroidogenic factor-1, but the placental strategy for transcription of P450scc employs cis-
acting elements different from those used in the adrenal strategy and is independent of
steroidogenic factor-1. Because placental expression of P450scc is required for human …