Current theories on the causes of inflammatory bowel disease

KA Papadakis, SR Targan - Gastroenterology Clinics of North America, 1999 - Elsevier
Chronic relapsing and remitting inflammation of the intestinal tract is the hallmark trait of
ulcerative colitis (UC) and Crohn's disease (CD), collectively termed inflammatory bowel
diseases (IBD). IBDs are common in the developed countries. 37 Their prevalence is
approximately 0.1% to 0.2%, and their incidence rate is about 2 to 4 per 100,000 population.
62 The first clinical signs of disease typically begin between adolescence and the third
decade of life. CD is characterized by transmural, patchy, granulomatous inflammation of …